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| Y-27632 dihydrochloride
CAS No.:146986-50-7
Synonyms: Cyclohexanecarboxamide,4-(1-aminoethyl)-N-4-pyridinyl-, [4(R)-trans]-;
(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)cyclohexanecarboamide;
Y 27632
Molecular Formula: C14H21N3O
Weight: 320.26
selective Rho kinase inhibitor
Purity: >99%
Biological Description
Potent, selective Rho kinase inhibitor. Ki values are 0.22, 0.30, 73, 25, >250 μM for ROCKI, ROCKII, PKCα, PKA and MLCK respectively. Muscle relaxant. Systemically active antinociceptive.
Useful References
Darenfed et al (2007) Molecular characterization of the effects of Y-27632. Cell Motil Cytoskeleton. 64:97-109 abstract
Ishizaki et al (2000) Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 57:976-83 abstract
Buyukafsar et al (2006) Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice. Eur J Pharmacol. 541:49-52 abstract
Chemical Information
(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride
Desiccate at +4°C
MW 320.26
Soluble in water to 100 mM
C14H21N3O
146986-50-7 |
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| chemical synthetic drug, pharmaceutical intermediates, Chemical raw materials, chemical antisepsis, flavor & essence, and food additive supplier |
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