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Giant Knotweed Extract Resveratrol 98% |
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유기화학원료와 중간체
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Additional_detail: Resveratrol 98%
Giant Knotweed Extract
Resveratrol 98%
Traditional Andmodernuses:
Huzhang ("tiger cane") or giant
knotweed is an east Asian species
(Polygonum cuspidatum), belonging
to the Polygonaceae family.
Documented uses in traditional
Chinese medicine date to the
first century BC, and
contemporary medical uses
supported by clinical results
include acute microbial
infections or viral hepatitis,
chemo- or radiation-induced
leukocytopenia, atherosclerosis,
and hyperlipidemia.
Pharmacology:
In animal experiments, huzhang
has exhibited antitussive,
antihistaminic, hypotensive,
vasodilating, cytotoxic, and
antioxidant properties, among
others. Huzhang is also a
concentrated source of
resveratrol (3,5,4≤-trihydroxy
stilbene), an antioxidant phenol
produced in response to fungi.
Resveratrol has also shown
antimutagenic activity in
bioassays conducted on bacteria
in vitro (umu and Ames tests).
And, in a recent investigation
conducted in vivo and in vitro,
resveratrol displayed
chemopreventive effects at three
critical stages of
carcinogenesis. Specifically,
resveratrol was found to 1)
induce phase II drug metabolizing
enzymes (antiinitiation); 2)
mediate anti-inflammatory effects
and inhibit cyclooxygenase and
hydro-peroxidase (antipromotion);
and 3) induce human promyelocytic
leukemia cell diferentiation
(antiprogression). Resveratrol
was also found to inhibit the
development of preneoplastic
lesions in vitro and
tumorigenesis in vivo. Very
recently, it was reported that
Huzhang extract is one of the
best active-oxygen scavengers for
the prevention of skin aging
induced by UV-irradiation and
free radical. Experiments
conducted in vivo indicate that
resveratrol is a potent
vasodilator and inhibitor of
platelet aggregation. Recent work
in dogs and humans indicate that
other concentrated sources of
resveratrol (i.e., red wine and
grape juice) eliminate cyclic
blood-flow reductions caused by
platelet-mediated thrombosis.
Active Compounds:
Huzhang is characterized by
anthraquinones and their
glycosides, napthoquinone,
3,5,4≤-trihydroxy stilbene
(i.e., resveratrol), piceid,
fallacinol, citreorosein,
questin, questinol,
protocatechuic acid, (+)
catechin, 2,5-dimethyl-7-
hydroxychromone, 7-hydroxy-4-
methoxy-5-methylcoumarin,
flavonols, polysaccharides, and
condensed tannins.
Regulatory Status:
Under U.S. law, huzhang extract
is regulated as a dietary
supplement. As of this writing,
no European governments had
issued monographs or regulations
for nutraceutical uses of
huzhang. NOTE: The statements in
this publication have not been
evaluated by the FDA.
Selected Reference:
Encyclopedia of Chinese Drugs.
Jiangsu Institute of Modern
Medicine, Shanghai Scientific and
Technical Publications, 1977.
[Chinese] Encyclopedia of Common
Natural Ingredients Used in
Foods, Drugs, and Cosmetics, by
Albert Leung, Ph.D. and Steven
Foster. Hitoshi Masaki et al.
Biol Pharm Bull. 18, 162-166,
1995. Huang WZ. Fujian
Zhongyiyao, 18(4), 27, 1987.
[Chinese] Kimura Y et al. Planta
Med, 48, 164, 1996. Meishang Jang
et al. Cancer chemopreventive
activity of resveratrol, a
natural product derived from
grapes. Science, vol. 275, 218-
220, 1997. Orsini, F. et al.
Isolation, synthesis, and
antiplatelet aggregation activity
of resveratrol 3-O-b-D
glucopyranoside and related
compounds. J Nat Prod. 60:1082-
87, 1997. Pharmacognosy,
Phytochemistry, Medicinal Plants,
by Prof. Jean Bruneton. Lavoisier
Tec & Doc/Intercept Ltd., 1995.
Records of Chinese Materia Medica
Vol. 1. Institute of Materia
Medica, Chinese Academy of
Sciences, 1982. [Chinese]
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