 오퍼게시판 |
|
|
 |
|
|
 |
제 목:
|
Sell Black Sesame Extract sesamin |
|
상품분류: |
유기화학원료와 중간체
|
|
등록분류: |
Offer to Sell |
|
내용: |
Additional_detail: Black Sesame Extract sesamin
sesamin Black Sesame Extract
Sesamum indicum L
sesamin Herb Source
Sesamum indicum L. Zanthoxylum
acanthapodium var. villosum
Huang. Piper longum
sesamin Molecular Formula and
Molecular Weight
C20H18O6
351.34
sesamin Melting Point
122 -123
sesamin Solubility
sesamin Freely soluble in
chloroform-benzene-acetic acid
and acetone.
sesamin Pharmacology
Antioxidant Bactericide
Insecticide Non-competitive D5-
desaturase inhibitor.
Sesamin is an all-natural
component stored in sesame seeds.
Its content is only about 0.5
percent. Through extracting
sesamin from sesame, and
experimenting in animals and
humans, the Japanese scientific
researchers have discovered that
sesamin has effects of preventing
hypertension and cardiovascular
hypertrophy, protecting liver,
resisting oxidation, reducing
cholesterol, and anti-cancer .
Effect of sesamin, a sesame
lignan, on the hepatic fatty acid
metabolism was examined in the
rat.
Increase of the dietary level of
sesamin progressively increased
the mitochondrial and peroxisomal
fatty acid oxidation rate.
Mitochondrial activity almost
doubled in rats fed a 0.5%
sesamin diet. Peroxisomal
activity became more than 10
times higher in rats fed a 0.5%
sesamin diet, compared to those
fed a sesamin-free diet. Dietary
sesamin also markedly increased
the hepatic activity and mRNA
levels
of various fatty acid oxidation
enzymes. In contrast, dietary
sesamin decreased the hepatic
activity
and mRNA abundance of lipogenic
enzymes. This was associated with
the down-regulation of sterol
regulatory element-binding
protein-1, a transcriptional
factor that regulates the
lipogenic enzyme gene
expression. Dietary sesamin
significantly decreased the
triacylglycerol secretion
accompanying the
increase in ketone body
production by the perfused rat
liver. It is apparent that
sesamin affects the fatty
acid metabolism and lipoprotein
production in the liver, and
hence lowers the serum lipid
levels. We
also developed several sesame
lines with seeds containing
sesamin and sesamolin at twice
the concentration
of conventional cultivars.
Compared to a conventional
cultivar, these lignan-rich
sesame seeds
increased the hepatic fatty acid
oxidation rate and lowered the
serum triacylglycerol level in
the rat.
Therefore, it is considered that
enrichment of the lignans
potentiates the characteristics
of sesame in
improving human health.
Sesamin, one of the lignans
present most abundantly
in sesame seed and oil (Fig. 1),
markedly influences the
lipid metabolism in experimental
animals. Sesamin feeding
is associated with a reduction of
serum lipid levels in
rodents7,8,22. This compound is
also effective in preventing
an increase in the serum
triacylglycerol level following
ethanol consumption in the rat1.
The cholesterollowering
effect of sesamin has also been
demonstrated in humans6. However,
the mechanism(s) underlying the
lipid-lowering effect of sesamin
remains to be clarified.
The changes in the rate of fatty
acid synthesis and oxidation
in the liver may possibly modify
serum lipid concentrations.
Alterations in fatty acid
synthesis25 and
oxidation10,11 which affect the
availability of fatty acids
for triacylglycerol synthesis,
and in turn modify the very
low density lipoprotein
production by the liver, may
affect the serum lipid levels. In
this context, we examined
the physiological activity of
sesamin in relation to
the hepatic fatty acid metabolism
in the rat.
|
연락처 |
| 담
당 자: |
lily liu |
| 회사주소: |
No.1038shanshuirenjia,KaiyuanRoad,Xingsha,Changsha,China |
| 전화번호: |
86-731-2967872 |
| 팩스번호:
|
86-731-2967861 |
| E - mail: |
lily@orgabnic-herb.com |
|
현재위치
: Home > Trade 
