 오퍼게시판 |
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제 목:
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Soy isoflavones |
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상품분류: |
유기화학원료와 중간체
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등록분류: |
Offer to Sell |
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내용: |
Additional_detail: Soy isoflavones have weak
estrogenic activity. The order of
activity in in vivo assays is
glycitein greater than genistein
greater than daidzein. They bind
to estrogen receptors-alpha and
beta. They appear to bind better
to estrogen receptor-beta than to
estrogen receptor-alpha.The most
studied of the soy isoflavones is
genistein. Genistein has been
found to have a number of
antioxidant activities. It is a
scavenger of reactive oxygen
species and inhibits lipid
peroxidation. It also inhibits
superoxide anion generation by
the enzyme xanthine oxidase. In
addition, genistein, in animal
experiments, has been found to
increase the activities of the
antioxidant enzymes superoxide
dismutase, glutathionine
peroxidase, catalase and
glutathione reductase. Daidzein
and glycitein also appear to have
reactive oxygen scavenging
activity. However, these
isoflavones have not been studied
as much as genistein
has.Regarding possible
anticarcinogenic activity, again
genistein has been the most
studied of the soy isoflavones.
Several mechanisms have been
proposed for genistein's possible
anticarcinogenic activity. These
include upregulation of
apoptosis, inhibition of
angiogenesis, inhibition of DNA
topoisomerase II and inhibition
of protein tyrosine kinases.
Other possible anti-prostate
cancer mechanisms include
inhibition of NF (nuclear factor)-
kappa B in prostate cancer cells,
downregulation of TGF
(transforming growth factor)-beta
and inhibition of EGF (epidermal
growth factor)- stimulated
growth. Genistein's anti-
estrogenic action may be another
possible mechanism to explain its
putative activity against breast
cancer. Additional possible anti-
breast cancer mechanisms include
inhibition of aromatase activity
and stimulation of sex hormone
binding globulin, both of which
might lower endogenous estrogen
levels.The possible anti-
atherogenic activity of soy
isoflavones may be accounted for,
in part, by their possible
antioxidant activity,
particularly with regard to
inhibition of lipid peroxidation
and oxidation of LDL.
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