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ÀÔ·ÂÀÏÀÚ: 2015-02-10
À¯È¿ÀÏÀÚ: 111470-99-6

Á¦¸ñ: Amlodipine besilate
  »óǰºÐ·ù: È­Çкñ·á¿Í ³ó¾à
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  ³»¿ë: Amlodipine besilate Synonyms: 2-[(2-AMINOETHOXY)-METHYL]-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER BENZENE SULFONATE;2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate;AMLODIPINE BENZENESULFONATE;AMLODIPINE BESILATE;AMLODIPINE BESYLATE;NORVASC;3,5-pyridinedicarboxylicacid,2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,;4-dihydro-6-methyl-,3-ethyl-5-methylester,monobenzenesulfonate CAS: 111470-99-6 MF: C26H31ClN2O8S MW: 567.05 Chemical Properties White Crystalline Solid Usage A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive Usage Angiotensin II inhibitor prodrug, antihypertensive Usage Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats. Biological Activity L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 ¥ì M).

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