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ÀÔ·ÂÀÏÀÚ: 2015-02-10
À¯È¿ÀÏÀÚ: 59865-13-3

Á¦¸ñ: Cyclosporin A
  »óǰºÐ·ù: È­Çкñ·á¿Í ³ó¾à
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  ³»¿ë: Cyclosporin A CYCLOSPORINE Synonyms: ol27-400;s7481f1;sandimmun;sandimmune;ANTIBIOTIC S 7481F1;ANTIBIOTIC S 7481FI;CICLOSPORIN;CICLOSPORIN A CAS: 59865-13-3,79217-60-0 MF: C62H111N11O12 MW: 1202.61 Chemical Properties White Powder Usage prothrombogenic agent Usage Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant. Cyclosporin A acts by binding to the protein, cyclophilin (immunophilin), in T-lymphocytes causing inhibition of calcineurin (protein phosphatase 2B). Cyclosporin A reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and NO synthesis induced by interleukin 1¥á, lipopolysaccharides and TNF¥á. Usage An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity. General Description White prismatic needles (from acetone) or white powder. Air & Water Reactions Slightly water soluble .

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