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2015-02-10 |
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59865-13-3 |
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Cyclosporin A |
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Offer to Sell |
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Cyclosporin A
CYCLOSPORINE
Synonyms: ol27-400;s7481f1;sandimmun;sandimmune;ANTIBIOTIC S 7481F1;ANTIBIOTIC S 7481FI;CICLOSPORIN;CICLOSPORIN A
CAS: 59865-13-3,79217-60-0
MF: C62H111N11O12
MW: 1202.61
Chemical Properties White Powder
Usage prothrombogenic agent
Usage Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant. Cyclosporin A acts by binding to the protein, cyclophilin (immunophilin), in T-lymphocytes causing inhibition of calcineurin (protein phosphatase 2B). Cyclosporin A reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and NO synthesis induced by interleukin 1¥á, lipopolysaccharides and TNF¥á.
Usage An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
General Description White prismatic needles (from acetone) or white powder.
Air & Water Reactions Slightly water soluble . |
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Ivy Young |
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No 496 Zhongshan Road, Wuhan City, Hubei Province, China 430064 |
¿ìÆí¹øÈ£: |
430064 |
ÀüȹøÈ£: |
86-027-50755963 |
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86-027-50755963 |
E - mail: |
ycwlb045@yccreate.com |
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