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2015-02-10 |
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24280-93-1 |
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Mycophenolic acid |
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Offer to Sell |
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Mycophenolic acid
Synonyms: 4-methyl-5-methoxy-7-hydroxy-6-(5-carboxy-3-methylpent-2-en-1-yl)-phthalide;6-(5-carboxy-3-methyl-2-pentenyl)-7-hydroxy-5-methoxy-4-methyl-phthalid;lilly-68618;melbex;micofenolicoacido;nsc-129185;(4E)-6-(1,3-DIHYDRO-4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-ISOBENZOFURANYL)-4-METHYL-4-HEXENOIC ACID;6-(4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-PHTHALANYL)-4-METHYL-4-HEXANOIC ACID
CAS: 24280-93-1
MF: C17H20O6
MW: 320.34
EINECS: 246-119-3
Chemical Properties White to Off-White Powder
Usage An antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.
Usage immune suppressant, antineoplastic, antiviral
Usage antineoplastic, progestin
Usage Mycophenolic acid is a common Penicillium metabolite first reported in the 1930s as a possible mycotoxin. Re-investigation showed mycophenolic acid to display broad antitumour, antiviral, antifungal and antiprotozoan activities. Its potent immunosuppressant activity led to its commercial development to prevent kidney transplant rejection. Mycophenolic acid acts by inhibiting inosine monophosphate dehydrogenase, controlling the rate of de novo purine synthesis in proliferating B and T lymphocytes.
Biological Activity Immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo . Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation. |
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Ivy Young |
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No 496 Zhongshan Road, Wuhan City, Hubei Province, China 430064 |
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430064 |
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86-027-50755963 |
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86-027-50755963 |
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ycwlb045@yccreate.com |
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