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ÀÔ·ÂÀÏÀÚ: 2015-02-10
À¯È¿ÀÏÀÚ: 21679-14-1

Á¦¸ñ: Fludarabine
  »óǰºÐ·ù: È­Çкñ·á¿Í ³ó¾à
  µî·ÏºÐ·ù: Offer to Sell
  ³»¿ë: Fludarabine Synonyms: 2-Fluoroadeninearabinoside;9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin;9-beta-d-arabinofuranosyl-2-fluoro-adenin;f-ara-a;6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE;9-bata-d-arabinofuranosyl-2-fluoroadenine;9-BETA-D-ARABINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE;9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE CAS: 21679-14-1 MF: C10H12FN5O4 MW: 285.23 EINECS: 244-525-5 Chemical Properties White Solid Usage Used as an antineoplastic Usage A STAT-1 activation inhibitor and a DNA synthesis inhibitor.? Usage phosphate as antineoplastic;inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase Usage Irreversible muscarinic agonist Usage DNA synthesis and methylation inhibitor;A cell permeable agent that interferes with DNA synthesis and repair; also inhibits RNA transcription Biological Activity Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 ¥ì M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Displays anticancer activity against hematological malignancies in vivo .

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